ESOXX® ONE is a medical device with a mechanical action that promotes the rapid relief of symptoms related to gastroesophageal reflux such as: heartburn, epigastric pain, acid reflux, irritating cough and dysphonia. Gastroesophageal reflux disease, known as GERD, is characterized by symptoms (heartburn, acid reflux, irritating cough and dysphonia) that may or may not be associated with inflammatory and erosive lesions of the esophageal mucosa. In general, GERD is exacerbated by the supine position and symptoms may be worse at night. ESOXX® ONE is the combination of hyaluronic acid and chondroitin sulphate that results in an original and innovative gastroesophageal mucosal defense barrier. The presence of a component with high bioadhesiveness (poloxamer 407) in the formulation of ESOXX® ONE that increases the stability of the adhesion of hyaluronic acid/chondroitin sulfate to the surface of the esophageal wall, contributes to the protection against the action of hydrochloric acid produced in the stomach . Chondroitin sulfate also promotes the natural repair process of the gastroesophageal mucosa.